Dr. Ramji Bhandari, an Associate Professor and the Bernard-Glickman Dean’s Professor in the Department of Biology, has received a continuing award as part of a nearly $1.5 M proposal, “Germline transmission of epigenetic alterations to offspring.” The study seeks to understand the the role of germline epigenetic alterations (epimutations) in reproductive impairment. In particular, the project seeks to determine whether inherited epimutations predispose current and future generations to increased reproductive health risks from exposure to emerging contaminants of concern. Bhandari’s study exposes medaka fish to BPA and Bisphenol S (BPS) chemicals to assess epimutations and also attempts to correct them using reprogrammable CRISPR-dCas9 epigenome editing in vivo.
Learn more about this project by reading the abstract on NIH RePORTER.
